Starting from hyperpolarized HDO, two-dimensional (2D) proton correlation maps of a peptide, either free in solution or interacting with liposomes, can be acquired in less than 60s, much faster than previous measurements which took hours to perform. Sensitivity-enhanced 2D proton correlation spectroscopy is a useful and straightforward tool for biochemistry and structural biology, as it does not recur to nitrogen-15 or carbon-13 isotope enrichment (Journal of the American Chemical Society 141, 12448-12452, (09/2019))

Recent studies showed that the timescales on which radiation doses are delivered in radiotherapy influences the cellular response. Upon radiation, reactive molecules are generated and persist, in various forms. Suitable molecular markers have to be adopted to monitor radiation effects, addressing relevant endogenous molecules that are accessible for investigation by noninvasive procedures and enable translation to clinical imaging. High sensitivity has to be attained for imaging molecular biomarkers as demonstrated recently by the use of dynamic nuclear polarization (DNP) for biomolecular observations in vivo and polarization storage in the form of long-lived states (Medical Physics, 46: e726-e734 (10/2019))